USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P23396 USC-OGP 2-DE database:  P23396 P23396 General information about the entry View entry in simple text format Entry name RS3_HUMAN Primary accession number P23396 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=40S ribosomal protein S3; EC=4.2.99.18 {ECO:0000269|PubMed:7775413}; AltName: Full=Small ribosomal subunit protein uS3 {ECO:0000303|PubMed:24524803};. Gene name Name=RPS3 ORFNames=OK/SW-cl.26 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1247: pI=5.77; Mw=31502 Cross-references UniProtKB/Swiss-Prot P23396; RS3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name RS3_HUMAN Primary accession number P23396 Secondary accession number(s) B2R7N5 J3KN86 Q498B5 Q8NI95 Sequence was last modified on  October 1, 1993 (version 2) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=40S ribosomal protein S3; EC=4.2.99.18 {ECO:0000269|PubMed:7775413}; AltName: Full=Small ribosomal subunit protein uS3 {ECO:0000303|PubMed:24524803}; Gene name Name=RPS3 ORFNames=OK/SW-cl.26 Encoded on Name=RPS3; ORFNames=OK/SW-cl.26 Keywords 3D-structure; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; DNA damage; DNA repair; DNA-binding; Isopeptide bond; Lyase; Membrane; Methylation; Mitochondrion; Mitochondrion inner membrane; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; Transcription; Transcription regulation; Translation regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U14990; AAB60336.1; -; mRNA EMBL U14991; AAB60337.1; -; mRNA EMBL U14992; AAB60338.1; -; mRNA EMBL X55715; CAA39248.1; -; mRNA EMBL S42658; AAB19349.2; -; mRNA EMBL AB061838; BAB79476.1; -; Genomic_DNA EMBL AY791291; AAV40835.1; -; Genomic_DNA EMBL AK313051; BAG35882.1; -; mRNA EMBL AP000744; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471076; EAW74963.1; -; Genomic_DNA EMBL BC003137; AAH03137.1; -; mRNA EMBL BC003577; AAH03577.1; -; mRNA EMBL BC013196; AAH13196.1; -; mRNA EMBL BC034149; AAH34149.1; -; mRNA EMBL BC071917; AAH71917.1; -; mRNA EMBL BC100284; AAI00285.1; -; mRNA EMBL L16016; AAA18095.1; -; Genomic_DNA EMBL AB062288; BAB93471.1; ALT_INIT; mRNA CCDS CCDS58161.1; -. [P23396-2]; . CCDS CCDS8236.1; -. [P23396-1]; . PIR A41247; R3HUS3; . RefSeq NP_000996.2; NM_001005.4. [P23396-1]; . RefSeq NP_001243731.1; NM_001256802.1. [P23396-1]; . RefSeq NP_001247435.1; NM_001260506.1. [P23396-2]; . RefSeq NP_001247436.1; NM_001260507.1; . UniGene Hs.546286; -; . UniGene Hs.740358; -; . PDB 1WH9; NMR; -; A=17-95 PDB 4UG0; EM; -; SD=1-243 PDB 4V6X; EM; 5.00 A; AD=1-243 PDB 5A2Q; EM; 3.90 A; D=1-243 PDB 5AJ0; EM; 3.50 A; BD=1-243 PDB 5FLX; EM; 3.90 A; D=1-243 PDB 5T2C; EM; 3.60 A; Aq=1-243 PDBsum 1WH9; -; . PDBsum 4UG0; -; . PDBsum 4V6X; -; . PDBsum 5A2Q; -; . PDBsum 5AJ0; -; . PDBsum 5FLX; -; . PDBsum 5T2C; -; . ProteinModelPortal P23396; -; . SMR P23396; -; . BioGrid 112102; 258; . DIP DIP-33177N; -; . IntAct P23396; 73; . MINT MINT-4999144; -; . STRING 9606.ENSP00000433821; -; . iPTMnet P23396; -; . PhosphoSitePlus P23396; -; . SwissPalm P23396; -; . BioMuta RPS3; -; . DMDM 417719; -; . EPD P23396; -; . MaxQB P23396; -; . PaxDb P23396; -; . PeptideAtlas P23396; -; . PRIDE P23396; -; . DNASU 6188; -; . Ensembl ENST00000278572; ENSP00000278572; ENSG00000149273. [P23396-2]; . Ensembl ENST00000524851; ENSP00000433821; ENSG00000149273. [P23396-1]; . Ensembl ENST00000527446; ENSP00000436971; ENSG00000149273. [P23396-1]; . Ensembl ENST00000531188; ENSP00000434643; ENSG00000149273. [P23396-1]; . GeneID 6188; -; . KEGG hsa:6188; -; . UCSC uc001owh.5; human. [P23396-1]; . CTD 6188; -; . DisGeNET 6188; -; . GeneCards RPS3; -; . HGNC HGNC:10420; RPS3; . HPA HPA063339; -; . MIM 600454; gene; . neXtProt NX_P23396; -; . OpenTargets ENSG00000149273; -; . PharmGKB PA34829; -; . eggNOG KOG3181; Eukaryota; . eggNOG COG0092; LUCA; . GeneTree ENSGT00390000008610; -; . HOGENOM HOG000210611; -; . HOVERGEN HBG002195; -; . InParanoid P23396; -; . KO K02985; -; . OMA QKFTEGY; -; . OrthoDB EOG091G0I8D; -; . PhylomeDB P23396; -; . TreeFam TF300901; -; . Reactome R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression; . Reactome R-HSA-156902; Peptide chain elongation; . Reactome R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane; . Reactome R-HSA-192823; Viral mRNA Translation; . Reactome R-HSA-2408557; Selenocysteine synthesis; . Reactome R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol; . Reactome R-HSA-72649; Translation initiation complex formation; . Reactome R-HSA-72689; Formation of a pool of free 40S subunits; . Reactome R-HSA-72695; Formation of the ternary complex; and subsequently; the 43S complex Reactome R-HSA-72702; Ribosomal scanning and start codon recognition; . Reactome R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit; . Reactome R-HSA-72764; Eukaryotic Translation Termination; . Reactome R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); . Reactome R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); . SIGNOR P23396; -; . ChiTaRS RPS3; human; . EvolutionaryTrace P23396; -; . GeneWiki RPS3; -; . GenomeRNAi 6188; -; . PRO PR:P23396; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000149273; -; . CleanEx HS_RPS3; -; . ExpressionAtlas P23396; baseline and differential; . Genevisible P23396; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB; . GO GO:0005783; C:endoplasmic reticulum; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB; . GO GO:0005759; C:mitochondrial matrix; IDA:UniProtKB; . GO GO:0072686; C:mitotic spindle; IDA:UniProtKB; . GO GO:0005730; C:nucleolus; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0005844; C:polysome; IDA:UniProtKB; . GO GO:0005840; C:ribosome; IDA:UniProtKB; . GO GO:0032587; C:ruffle membrane; IDA:UniProtKB; . GO GO:0003684; F:damaged DNA binding; IDA:UniProtKB; . GO GO:0003677; F:DNA binding; IDA:UniProtKB; . GO GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IDA:UniProtKB; . GO GO:0004520; F:endodeoxyribonuclease activity; IDA:UniProtKB; . GO GO:0019899; F:enzyme binding; IPI:UniProtKB; . GO GO:0030544; F:Hsp70 protein binding; IDA:UniProtKB; . GO GO:0051879; F:Hsp90 protein binding; IDA:UniProtKB; . GO GO:0051536; F:iron-sulfur cluster binding; NAS:UniProtKB; . GO GO:0019900; F:kinase binding; IPI:UniProtKB; . GO GO:0008017; F:microtubule binding; IDA:UniProtKB; . GO GO:0003729; F:mRNA binding; IDA:UniProtKB; . GO GO:0032357; F:oxidized purine DNA binding; IDA:UniProtKB; . GO GO:0032358; F:oxidized pyrimidine DNA binding; IDA:UniProtKB; . GO GO:0051018; F:protein kinase A binding; IPI:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0070181; F:small ribosomal subunit rRNA binding; IDA:UniProtKB; . GO GO:0003735; F:structural constituent of ribosome; IDA:UniProtKB; . GO GO:0032183; F:SUMO binding; IPI:UniProtKB; . GO GO:0097100; F:supercoiled DNA binding; IDA:UniProtKB; . GO GO:0008134; F:transcription factor binding; IPI:UniProtKB; . GO GO:0015631; F:tubulin binding; IDA:UniProtKB; . GO GO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:UniProtKB; . GO GO:0006915; P:apoptotic process; IEA:UniProtKB-KW; . GO GO:0051301; P:cell division; IEA:UniProtKB-KW; . GO GO:0006974; P:cellular response to DNA damage stimulus; IEP:UniProtKB; . GO GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB; . GO GO:0007059; P:chromosome segregation; IMP:UniProtKB; . GO GO:0042769; P:DNA damage response; detection of DNA damage; IDA:UniProtKB GO GO:0006281; P:DNA repair; IEA:UniProtKB-KW; . GO GO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW; . GO GO:0045738; P:negative regulation of DNA repair; IMP:UniProtKB; . GO GO:0031397; P:negative regulation of protein ubiquitination; IDA:UniProtKB; . GO GO:0017148; P:negative regulation of translation; IDA:UniProtKB; . GO GO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; TAS:Reactome GO GO:2001235; P:positive regulation of apoptotic signaling pathway; IDA:UniProtKB; . GO GO:1905053; P:positive regulation of base-excision repair; IDA:UniProtKB; . GO GO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IMP:UniProtKB; . GO GO:1902546; P:positive regulation of DNA N-glycosylase activity; IDA:UniProtKB; . GO GO:0045739; P:positive regulation of DNA repair; IDA:UniProtKB; . GO GO:0032079; P:positive regulation of endodeoxyribonuclease activity; IDA:UniProtKB; . GO GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB; . GO GO:1902231; P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IMP:UniProtKB; . GO GO:0043507; P:positive regulation of JUN kinase activity; IMP:UniProtKB; . GO GO:0031116; P:positive regulation of microtubule polymerization; IMP:UniProtKB; . GO GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IDA:UniProtKB; . GO GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB; . GO GO:0006355; P:regulation of transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0006979; P:response to oxidative stress; IDA:UniProtKB; . GO GO:0061481; P:response to TNF agonist; IDA:UniProtKB; . GO GO:0006364; P:rRNA processing; TAS:Reactome; . GO GO:0051225; P:spindle assembly; IMP:UniProtKB; . GO GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW GO GO:0006412; P:translation; NAS:UniProtKB; . GO GO:0006413; P:translational initiation; NAS:UniProtKB; . GO GO:0019083; P:viral transcription; TAS:Reactome; . Gene3D 3.30.1140.32; -; 1; . Gene3D 3.30.300.20; -; 1; . InterPro IPR015946; KH_dom-like_a/b; . InterPro IPR004044; KH_dom_type_2; . InterPro IPR009019; KH_prok-type; . InterPro IPR001351; Ribosomal_S3_C; . InterPro IPR018280; Ribosomal_S3_CS; . InterPro IPR005703; Ribosomal_S3_euk/arc; . Pfam PF07650; KH_2; 1; . SUPFAM SSF54814; SSF54814; 1; . SUPFAM SSF54821; SSF54821; 1; . TIGRFAMs TIGR01008; uS3_euk_arch; 1; . PROSITE PS50823; KH_TYPE_2; 1; . PROSITE PS00548; RIBOSOMAL_S3; 1; .

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